DNA Topoisomerases and Cancer

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DNA Topoisomerases and Cancer

DNA Topoisomerases and Cancer
English | 2011 | ISBN: 1461403227 | 454 pages | PDF | 5,5 MB

DNA topoisomerases are present in all living organisms and are essential to maintaining the helical structure of DNA. They are highly relevant for cancer because a number of anti-cancer drugs selectively target two of the human enzymes, DNA topoisomerases I and II. Those drugs convert topoisomerases into cellular poisons by trapping the enzymes as they cleave DNA.
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Tags: Topoisomerases, Cancer

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