The Evaluation of Surrogate Endpoints by Tomasz Burzykowski

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The Evaluation of Surrogate Endpoints by Tomasz Burzykowski
The Evaluation of Surrogate Endpoints (Statistics for Biology and Health) by Tomasz Burzykowski
English | Mar 30, 2006 | ISBN: 0387202773 | 427 Pages | PDF | 3 MB

Both humanitarian and commercial considerations have spurred intensive search for methods to reduce the time and cost required to develop new therapies. The identification and use of surrogate endpoints, i.e., measures that can replace or supplement other endpoints




in evaluations of experimental treatments or other interventions, is a general strategy that has stimulated both enthusiasm and skepticism. Surrogate endpoints are useful when they can be measured earlier, more conveniently, or more frequently than the 'true' endpoints of primary interest. Regulatory agencies around the globe, particularly in the United States, Europe, and Japan, are introducing provisions and policies relating to the use of surrogate endpoints in registration studies. But how can one establish the adequacy of a surrogate? What kind of evidence is needed, and what statistical methods portray that evidence most appropriately? This book offers a balanced account on this controversial topic.








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Tags: Evaluation, Surrogate, Endpoints, Tomasz, Burzykowski

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