"Neurodegenerative Diseases: Processes, Prevention, Protection and Monitoring" ed. by Raymond Chuen-Chung Chang
ITAe | 2011 | ISBN: 9789533074856 | 569 pages | PDF | 46 MB
This book focuses on biological mechanisms, prevention, neuroprotection and even monitoring of disease progression. The book emphasizes the general biological processes of neurodegeneration in different neurodegenerative diseases. This book is suitable for different readers: college students can use it as a textbook; researchers in academic institutions and pharmaceutical companies can take it as updated research information; health care professionals can take it as a reference book, even patients' families, relatives and friends can take it as a good basis to understand neurodegenerative diseases.
The first three sections introduce how toxic proteins, intracellular calcium and oxidative stress affect different biological signaling pathways or molecular machineries to inform neurons to undergo degeneration. A section discusses how neighboring glial cells modulate or promote neurodegeneration.
In the next section an evaluation is given of how hormonal and metabolic control modulate disease progression, which is followed by a section exploring some preventive methods using natural products and new pharmacological targets. Authors explore how medical devices facilitate patient monitoring.
Part 1 Toxic Proteins and Disturbance of Neuronal Functions in Neurodegeneration
1 What is the Link Between Protein Aggregation and Interneuronal Lesion Propagation in Neurodegenerative Disease?
2 Roles of Microtubules in Maintenance of Nerve Cell Networks
Part 2 Oxidative Stress and Neurodegeneration
3 Oxidative Stress and Neurodegenerative Disease
4 Free Radicals in Neurodegenerative Diseases: Modulation by Palladium a-Lipoic Acid Complex
5 Docosahexaenoic Acid (DHA), in the Prevention and Treatment of Neurodegenerative Diseases
6 Effect of Zinc and DHA on Expression Levels and Post-Translational Modifications of Histones H3 and H4 in Human Neuronal Cells
7 Free Radicals, Neuronal Death and Neuroprotection
Part 3 Intracellular Signaling of Neurodegeneration
8 Neuropathological Disorders and Calcium Independent Forms of PhospholipaseA2 Activities in the Brain
9 ASK1 and Its Role in Neurodegenerative Diseases
10 Role of Connexin Hemichannels in Neurodegeneration
Part 4 Roles of Glial Cells in Neurodegeneration
11 Role of Astrocytes in Neurodegenerative Diseases
12 Alteration of Neuron-Glia Interactions in Neurodegeneration: Molecular Biomarkers and Therapeutic Strategy
13 Microglia, Calcification and Neurodegenerative Diseases
14 Analysis of the Impact of CD200 on Neurodegenerative Diseases
Part 5 Hormonal Control and Metabolism in Neurodegeneration
15 Hormonal Signaling Systems of the Brain in Diabetes Mellitus
16 Can VEGF-B Be Used to Treat Neurodegenerative Diseases?
17 Power of a Metabonomic Approach to Investigate an Unknown Nervous Disease
Part 6 Prevention. Protection and Monitoring of Neurodegeneration
18 Extract of Achillea fragrantissima Downregulates ROS Production and Protects Astrocytes from Oxidative-Stress-Induced Cell Death
19 Quantification of Volumetric Changes of Brain in Neurodegenerative Diseases Using Magnetic Resonance Imaging and Stereology
20 Acid-Sensing Ion Channels in Neurodegenerative Diseases: Potential Therapeutic Target
21 Genome Profiling and Potential Biomarkers in Neurodegenerative Disorders
22 Immunization with Neural-Derived Peptides as a Potential Therapy in Neurodegenerative Diseases
23 Neurodegenerative Disease Monitoring Using a Portable Wireless Sensor Device
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