High-Throughput Screening Assays in Toxicology
Humana Press | Pharmacology & Toxicology | September 13, 2016 | ISBN-10: 1493963449 | 175 pages | pdf | 7.22 mb
Editors: Zhu, Hao, Xia, Menghang (Eds.)
Includes cutting-edge methods and protocols for HTS assays to examine toxicity
Provides step-by-step detail essential for reproducible results
Contains key notes and implementation advice from the experts
This book focuses on recently developed High Throughput Screening (HTS) assay protocols, many involved in the ToxCast and/or Tox21 initiatives, and the relevant HTS data analysis techniques. Divided into three sections, in vitro assays, in vivo assays, and computational techniques to analyze HTS data are all examined. Written for the highly successful Methods in Molecular Biology series, most chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, High Throughput Screening Assays in Toxicology serves as a valuable reference resource for translating new HTS techniques into standardized chemical toxicity assessment tools in order to advance modern toxicology research to a new era where HTS techniques can partially replace the prevailing animal models.